Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells

Endothelial dysfunction caused by the combined action of disturbed flow, inflammatory mediators and oxidants derived from cigarette smoke is known to promote coronary atherosclerosis and increase the likelihood of myocardial infarctions and strokes. Conversely, laminar flow protects against endothel...

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Publicado en:Sci Rep
Main Authors: Teasdale, Jack E., Hazell, Georgina G. J., Peachey, Alasdair M. G., Sala-Newby, Graciela B., Hindmarch, Charles C. T., McKay, Tristan R., Bond, Mark, Newby, Andrew C., White, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216376/
https://ncbi.nlm.nih.gov/pubmed/28059114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39945
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