Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate

To identify novel effectors and processes regulated by PI3K pathway activation, we performed an unbiased phosphoproteomic screen comparing two common events of PI3K deregulation in cancer: oncogenic Pik3ca mutation (Pik3ca(H1047R)) and deletion of Pten. Using mouse embryonic fibroblast (MEF) models...

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Publicado en:Sci Rep
Autores principales: Moniz, Larissa S., Surinova, Silvia, Ghazaly, Essam, Velasco, Lorena Gonzalez, Haider, Syed, Rodríguez-Prados, Juan Carlos, Berenjeno, Inma M., Chelala, Claude, Vanhaesebroeck, Bart
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216349/
https://ncbi.nlm.nih.gov/pubmed/28059163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39985
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