Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis. The mechanism by which this occurs is unknown. Here we show that ca...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Rogers, Corey, Fernandes-Alnemri, Teresa, Mayes, Lindsey, Alnemri, Diana, Cingolani, Gino, Alnemri, Emad S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216131/
https://ncbi.nlm.nih.gov/pubmed/28045099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14128
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