3K3A-APC stimulates post-ischemic neuronal repair by human neural stem cells in mice

Activated protein C (APC) is a blood protease with anticoagulant activity and cell-signaling activities mediated by activation of protease-activated receptors 1 and 3 (PAR1, PAR3) via non-canonical cleavage(1). Recombinant APC and/or its analogs with reduced (>90%) anticoagulant activity such as...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Wang, Yaoming, Zhao, Zhen, Rege, Sanket V., Wang, Min, Si, Gabriel, Zhou, Yi, Wang, Su, Griffin, John H., Goldman, Steven A., Zlokovic, Berislav V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215920/
https://ncbi.nlm.nih.gov/pubmed/27548576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4154
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