Polymyxin Combinations: Pharmacokinetics and Pharmacodynamics for Rationale Use

Since their reintroduction into the clinic in the 1980s, the polymyxin antibiotics colistin—administered intravenously as an inactive prodrug, colistin methanesulfonate (CMS)—and polymyxin B have assumed an important role as salvage therapy for otherwise untreatable gram-negative infections. However...

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Udgivet i:Pharmacotherapy
Main Authors: Bergen, Phillip J., Bulman, Zackery P., Saju, Sarith, Bulitta, Juergen B., Landersdorfer, Cornelia, Forrest, Alan, Li, Jian, Nation, Roger L., Tsuji, Brian T.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215892/
https://ncbi.nlm.nih.gov/pubmed/25630411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phar.1537
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