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Functionality and Robustness of Injured Connectomic Dynamics in C. elegans: Linking Behavioral Deficits to Neural Circuit Damage

Using a model for the dynamics of the full somatic nervous system of the nematode C. elegans, we address how biological network architectures and their functionality are degraded in the presence of focal axonal swellings (FAS) arising from neurodegenerative disease and/or traumatic brain injury. Usi...

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Publicat a:PLoS Comput Biol
Autors principals: Kunert, James M., Maia, Pedro D., Kutz, J. Nathan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215891/
https://ncbi.nlm.nih.gov/pubmed/28056097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005261
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