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Mass spectrometry-based proteomics of oxidative stress: Identification of 4-hydroxy-2-nonenal (HNE) adducts of amino acids using lysozyme and bovine serum albumin as model proteins

Modification of proteins by 4-hydroxy-2-nonenal (HNE), a reactive by-product of ω6 polyunsaturated fatty acid oxidation, on specific amino acid residues is considered a biomarker for oxidative stress, as occurs in many metabolic, hereditary, and age-related diseases. HNE modification of amino acids...

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Bibliografski detalji
Izdano u:Electrophoresis
Glavni autori: Aslebagh, Roshanak, Pfeffer, Bruce A., Fliesler, Steven J., Darie, Costel C.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215750/
https://ncbi.nlm.nih.gov/pubmed/27184861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/elps.201600134
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