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Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer

The formation of a correctly folded and natively glycosylated HIV-1 viral spike is dependent on protease cleavage of the gp160 precursor protein in the Golgi apparatus. Cleavage induces a compact structure which not only renders the spike capable of fusion but also limits further maturation of its e...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Behrens, Anna-Janina, Harvey, David J., Milne, Emilia, Cupo, Albert, Kumar, Abhinav, Zitzmann, Nicole, Struwe, Weston B., Moore, John P., Crispin, Max
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215339/
https://ncbi.nlm.nih.gov/pubmed/27807235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01894-16
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