Replacement of Porcine CD163 Scavenger Receptor Cysteine-Rich Domain 5 with a CD163-Like Homolog Confers Resistance of Pigs to Genotype 1 but Not Genotype 2 Porcine Reproductive and Respiratory Syndrome Virus

CD163 knockout (KO) pigs are resistant to infection with genotype 2 (type 2) porcine reproductive and respiratory syndrome virus (PRRSV). Furthermore, the substitution of CD163 scavenger receptor cysteine-rich (SRCR) domain 5 with a homolog of human CD163-like (hCD163L1) SRCR 8 domain confers resist...

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Vydáno v:J Virol
Hlavní autoři: Wells, Kevin D., Bardot, Rachel, Whitworth, Kristin M., Trible, Benjamin R., Fang, Ying, Mileham, Alan, Kerrigan, Maureen A., Samuel, Melissa S., Prather, Randall S., Rowland, Raymond R. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215333/
https://ncbi.nlm.nih.gov/pubmed/27847356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01521-16
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