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Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27(KIP1)–Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression
The mammalian G(1)-S phase transition is controlled by the opposing forces of cyclin-dependent kinases (CDK) and the retinoblastoma protein (pRB). Here, we present evidence for systems-level control of cell cycle arrest by pRB-E2F and p27-CDK regulation. By introducing a point mutant allele of pRB t...
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| Pubblicato in: | Mol Cell Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5214858/ https://ncbi.nlm.nih.gov/pubmed/27821477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00561-16 |
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