Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice

Erythrocytosis is driven mainly by erythropoietin, which is regulated by hypoxia-inducible factor (HIF). Mutations in HIF prolyl 4-hydroxylase 2 (HIF-P4H-2) (PHD2/EGLN1), the major downregulator of HIFα subunits, are found in familiar erythrocytosis, and large-spectrum conditional inactivation of HI...

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Bibliografske podrobnosti
izdano v:Mol Cell Biol
Main Authors: Myllymäki, Mikko N. M., Määttä, Jenni, Dimova, Elitsa Y., Izzi, Valerio, Väisänen, Timo, Myllyharju, Johanna, Koivunen, Peppi, Serpi, Raisa
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214854/
https://ncbi.nlm.nih.gov/pubmed/27821476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00529-16
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