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Profile of retigabine-induced neuronal apoptosis in the developing rat brain

OBJECTIVE: Acute neonatal exposure to some, but not all, anticonvulsant drugs induces a profound increase in neuronal apoptosis in rats. Phenobarbital, and phenytoin induce apoptosis at therapeutically-relevant dose range, lamotrigine and carbamazepine do so only at supratherapeutic doses or in poly...

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Publicat a:Epilepsia
Autors principals: Brown, Lindsay, Gutherz, Samuel, Kulick, Catherine, Soper, Colin, Kondratyev, Alexei, Forcelli, Patrick A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214840/
https://ncbi.nlm.nih.gov/pubmed/26865186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.13335
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