Brief postnatal exposure to phenobarbital impairs passive-avoidance learning and sensorimotor gating in rats

Phenobarbital is the most commonly utilized drug for the treatment of neonatal seizures. However, mounting preclinical evidence suggests that even brief exposure to phenobarbital in the neonatal period can induce neuronal apoptosis, alterations in synaptic development, and long-lasting changes in be...

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Main Authors: Gutherz, Samuel B., Kulick, Catherine V., Soper, Colin, Kondratyev, Alexei, Gale, Karen, Forcelli, Patrick A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170015/
https://ncbi.nlm.nih.gov/pubmed/25112558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yebeh.2014.07.010
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