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Intracellular pH and the control of multidrug resistance.

Many anticancer drugs are classified as either weak bases or molecules whose binding to cellular structures is pH dependent. Accumulation of these drugs within tumor cells should be affected by transmembrane pH gradients. Indeed, development of multidrug resistance (MDR) in tumor cells has been corr...

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Autors principals: Simon, S, Roy, D, Schindler, M
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC521467/
https://ncbi.nlm.nih.gov/pubmed/8302842
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