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Inhibition of intracellular pH control and relationship to cytotoxicity of chlorambucil and vinblastine.
The uptake and cytotoxicity of weakly acidic or basic chemotherapeutic agents is determined in part by passive diffusion along the pH gradient between the intracellular and extracellular compartments. In vivo it is known that tumour extracellular pH is more acidic than intracellular pH. Using CaNT m...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
1996
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2150010/ https://ncbi.nlm.nih.gov/pubmed/8763851 |
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