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Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain

Myelin basic protein (MBP) is an auto-antigen able to induce intractable pain from innocuous mechanical stimulation (mechanical allodynia). The mechanisms provoking this algesic MBP activity remain obscure. Our present study demonstrates that membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14)...

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Detalhes bibliográficos
Publicado no:Brain Behav Immun
Main Authors: Hong, Sanghyun, Remacle, Albert G., Shiryaev, Sergei A., Choi, Wonjun, Hullugundi, Swathi, Dolkas, Jennifer, Angert, Mila, Nishihara, Tasuku, Yaksh, Tony L., Strongin, Alex Y., Shubayev, Veronica I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214638/
https://ncbi.nlm.nih.gov/pubmed/27833045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2016.11.003
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