Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma

Follicular lymphoma (FL) is typically an indolent disease, but 30-40% of FL cases transform into an aggressive lymphoma (tFL) with a poor prognosis. To identify the genetic changes that drive this transformation, we sequenced the exomes of 12 cases with paired FL and tFL biopsies, and identified 45...

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Udgivet i:Leukemia
Main Authors: Bouska, Alyssa, Zhang, Weiwei, Gong, Qiang, Iqbal, Javeed, Scuto, Anna, Vose, Julie, Ludvigsen, Maja, Fu, Kai, Weisenburger, Dennis D., Greiner, Timothy C., Gascoyne, Randy D., Rosenwald, Andreas, Ott, German, Campo, Elias, Rimsza, Lisa M., Delabie, Jan, Jaffe, Elaine S., Braziel, Rita M., Connors, Joseph M., Wu, Chung-I, Staudt, Louis M., D'Amore, Francesco, McKeithan, Timothy W., Chan, Wing C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214175/
https://ncbi.nlm.nih.gov/pubmed/27389057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.175
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