Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma

Follicular lymphoma (FL) is typically an indolent disease, but 30-40% of FL cases transform into an aggressive lymphoma (tFL) with a poor prognosis. To identify the genetic changes that drive this transformation, we sequenced the exomes of 12 cases with paired FL and tFL biopsies, and identified 45...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Leukemia
Prif Awduron: Bouska, Alyssa, Zhang, Weiwei, Gong, Qiang, Iqbal, Javeed, Scuto, Anna, Vose, Julie, Ludvigsen, Maja, Fu, Kai, Weisenburger, Dennis D., Greiner, Timothy C., Gascoyne, Randy D., Rosenwald, Andreas, Ott, German, Campo, Elias, Rimsza, Lisa M., Delabie, Jan, Jaffe, Elaine S., Braziel, Rita M., Connors, Joseph M., Wu, Chung-I, Staudt, Louis M., D'Amore, Francesco, McKeithan, Timothy W., Chan, Wing C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214175/
https://ncbi.nlm.nih.gov/pubmed/27389057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.175
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