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Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.

We have built a model of the specificity pocket of the protease of hepatitis C virus on the basis of the known structures of trypsin-like serine proteases and of the conservation pattern of the protease sequences among various hepatitis C strains. The model allowed us to predict that the substrate o...

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Autors principals: Pizzi, E, Tramontano, A, Tomei, L, La Monica, N, Failla, C, Sardana, M, Wood, T, De Francesco, R
Format: Artigo
Idioma:Inglês
Publicat: 1994
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC521417/
https://ncbi.nlm.nih.gov/pubmed/8302861
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