Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a common heart disease with a prevalence of 1 in 500 in the general population. Several mutations in genes encoding cardiac proteins have been found in HCM patients, but these changes do not predict occurrence or prognosis and the molecular mechanisms underlying...

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Publicado en:JCI Insight
Autores principales: Kimura, Hirotaka, Eguchi, Satoshi, Sasaki, Junko, Kuba, Keiji, Nakanishi, Hiroki, Takasuga, Shunsuke, Yamazaki, Masakazu, Goto, Akiteru, Watanabe, Hiroyuki, Itoh, Hiroshi, Imai, Yumiko, Suzuki, Akira, Mizushima, Noboru, Sasaki, Takehiko
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5213877/
https://ncbi.nlm.nih.gov/pubmed/28097232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89462
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