Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a common heart disease with a prevalence of 1 in 500 in the general population. Several mutations in genes encoding cardiac proteins have been found in HCM patients, but these changes do not predict occurrence or prognosis and the molecular mechanisms underlying...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Kimura, Hirotaka, Eguchi, Satoshi, Sasaki, Junko, Kuba, Keiji, Nakanishi, Hiroki, Takasuga, Shunsuke, Yamazaki, Masakazu, Goto, Akiteru, Watanabe, Hiroyuki, Itoh, Hiroshi, Imai, Yumiko, Suzuki, Akira, Mizushima, Noboru, Sasaki, Takehiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5213877/
https://ncbi.nlm.nih.gov/pubmed/28097232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89462
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