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Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters

Angiotensin-converting enzyme (ACE) 2 is a homolog to the carboxypeptidase ACE, which generates angiotensin II, the main active peptide of renin–angiotensin system (RAS). After the cloning of ACE2 in 2000, three major ACE2 functions have been described so far. First ACE2 has emerged as a potent nega...

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Bibliographic Details
Published in:Pharmacol Ther
Main Authors: Kuba, Keiji, Imai, Yumiko, Ohto-Nakanishi, Takayo, Penninger, Josef M.
Format: Artigo
Language:Inglês
Published: Elsevier Inc. 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112678/
https://ncbi.nlm.nih.gov/pubmed/20599443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2010.06.003
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