Breakpoints of gross deletions coincide with non-B DNA conformations

Genomic rearrangements are a frequent source of instability, but the mechanisms involved are poorly understood. A 2.5-kbp poly(purine·pyrimidine) sequence from the human PKD1 gene, known to form non-B DNA structures, induced long deletions and other instabilities in plasmids that were mediated by mi...

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Main Authors: Bacolla, Albino, Jaworski, Adam, Larson, Jacquelynn E., Jakupciak, John P., Chuzhanova, Nadia, Abeysinghe, Shaun S., O'Connell, Catherine D., Cooper, David N., Wells, Robert D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC521098/
https://ncbi.nlm.nih.gov/pubmed/15377784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405974101
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