miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation

BACKGROUND: Previously we found that smooth muscle cell (SMC)‐specific knockout of miR‐17~92 attenuates hypoxia‐induced pulmonary hypertension. However, the mechanism underlying miR‐17~92‐mediated pulmonary artery SMC (PASMC) proliferation remains unclear. We sought to investigate whether miR‐17~92...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Chen, Tianji, Zhou, Qiyuan, Tang, Haiyang, Bozkanat, Melike, Yuan, Jason X.‐J., Raj, J. Usha, Zhou, Guofei
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5210422/
https://ncbi.nlm.nih.gov/pubmed/27919930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.004510
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