Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

BACKGROUND: Prophylactic and therapeutic vaccines often depend upon a strong activation of the innate immune system to drive a potent adaptive immune response, often mediated by a strong adjuvant. For a number of adjuvants immunological readouts may not be consistent across species. METHODS: In this...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Edwards, Darin K., Jasny, Edith, Yoon, Heesik, Horscroft, Nigel, Schanen, Brian, Geter, Tanya, Fotin-Mleczek, Mariola, Petsch, Benjamin, Wittman, Vaughan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5210268/
https://ncbi.nlm.nih.gov/pubmed/28049494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-1111-6
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