Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy

Cisplatin is a widely used chemotherapy drug, despite its significant ototoxic side effects. To date, the mechanism of cisplatin‐induced ototoxicity remains unclear, and hearing preservation during cisplatin‐based chemotherapy in patients is lacking. We found activation of the ATM‐Chk2‐p53 pathway t...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Benkafadar, Nesrine, Menardo, Julien, Bourien, Jérôme, Nouvian, Régis, François, Florence, Decaudin, Didier, Maiorano, Domenico, Puel, Jean‐Luc, Wang, Jing
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5210089/
https://ncbi.nlm.nih.gov/pubmed/27794029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606230
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