Improvement of whole-cell transamination with Saccharomyces cerevisiae using metabolic engineering and cell pre-adaptation

BACKGROUND: Whole-cell biocatalysis based on metabolically active baker’s yeast with engineered transamination activity can be used to generate molecules carrying a chiral amine moiety. A prerequisite is though to express efficient ω-transaminases and to reach sufficient intracellular precursor leve...

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Udgivet i:Microb Cell Fact
Main Authors: Weber, Nora, Gorwa-Grauslund, Marie, Carlquist, Magnus
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209827/
https://ncbi.nlm.nih.gov/pubmed/28049528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-016-0615-3
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