Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2

BACKGROUND: Asthma is characterized by type 2 T-helper cell (Th2) inflammation, goblet cell hyperplasia, airway hyperreactivity, and airway fibrosis. Monocyte chemoattractant protein-1 (MCP-1 or CCL2) and its receptor, CCR2, have been shown to play important roles in the development of Th2 inflammat...

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Detalhes bibliográficos
Main Authors: Koth, Laura L, Rodriguez, Madeleine W, Bernstein, Xin Liu, Chan, Salina, Huang, Xiaozhu, Charo, Israel F, Rollins, Barrett J, Erle, David J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC520828/
https://ncbi.nlm.nih.gov/pubmed/15377395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-5-12
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