Neuronal eotaxin and the effects of ccr3 antagonist on airway hyperreactivity and M2 receptor dysfunction

Eosinophils cluster around airway nerves in patients with fatal asthma and in antigen-challenged animals. Activated eosinophils release major basic protein, which blocks inhibitory M2 muscarinic receptors (M2Rs) on nerves, increasing acetylcholine release and potentiating vagally mediated bronchocon...

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Detalhes bibliográficos
Main Authors: Fryer, Allison D., Stein, Louis H., Nie, Zhenying, Curtis, Damian E., Evans, Christopher M., Hodgson, Simon T., Jose, Peter J., Belmonte, Kristen E., Fitch, Erin, Jacoby, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1319219/
https://ncbi.nlm.nih.gov/pubmed/16374515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25423
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