p70S6K1 (S6K1)-mediated Phosphorylation Regulates Phosphatidylinositol 4-Phosphate 5-Kinase Type I γ Degradation and Cell Invasion

Phosphatidylinositol 4-phosphate 5-kinase type I γ (PIPKIγ90) ubiquitination and subsequent degradation regulate focal adhesion assembly, cell migration, and invasion. However, it is unknown how upstream signals control PIPKIγ90 ubiquitination or degradation. Here we show that p70S6K1 (S6K1), a down...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Jafari, Naser, Zheng, Qiaodan, Li, Liqing, Li, Wei, Qi, Lei, Xiao, Jianyong, Gao, Tianyan, Huang, Cai
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207268/
https://ncbi.nlm.nih.gov/pubmed/27780861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.742742
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