Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme

Mediator plays an integral role in activation of RNA polymerase II (Pol II) transcription. A key step in activation is binding of Mediator to Pol II to form the Mediator-Pol II holoenzyme. Here, we exploit a combination of biochemistry and macromolecular EM to investigate holoenzyme assembly. We ide...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Sato, Shigeo, Tomomori-Sato, Chieri, Tsai, Kuang-Lei, Yu, Xiaodi, Sardiu, Mihaela, Saraf, Anita, Washburn, Michael P., Florens, Laurence, Asturias, Francisco J., Conaway, Ronald C., Conaway, Joan W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207194/
https://ncbi.nlm.nih.gov/pubmed/27821593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.756098
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