Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions

Previous studies have shown that extracellular signal-regulated kinase 1/2 (ERK1/2) directly inhibits mitochondrial function during cellular injury. We evaluated the role of ERK1/2 on the expression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) gene, a master regulator of m...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Collier, Justin B., Whitaker, Ryan M., Eblen, Scott T., Schnellmann, Rick G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207191/
https://ncbi.nlm.nih.gov/pubmed/27875304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754762
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