Evolution of Negative Cooperativity in Glutathione Transferase Enabled Preservation of Enzyme Function

Negative cooperativity in enzyme reactions, in which the first event makes subsequent events less favorable, is sometimes well understood at the molecular level, but its physiological role has often been obscure. Negative cooperativity occurs in human glutathione transferase (GST) GSTP1-1 when it bi...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Bocedi, Alessio, Fabrini, Raffaele, Lo Bello, Mario, Caccuri, Anna Maria, Federici, Giorgio, Mannervik, Bengt, Cornish-Bowden, Athel, Ricci, Giorgio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207182/
https://ncbi.nlm.nih.gov/pubmed/27815499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749507
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