Identification of Lysophosphatidic Acid Receptor 1 in Astroglial Cells as a Target for Glial Cell Line-derived Neurotrophic Factor Expression Induced by Antidepressants

Preclinical and clinical evidence suggests that glial cell line-derived neurotrophic factor (GDNF) is important in the therapeutic effect of antidepressants. A previous study demonstrated that the tricyclic antidepressant amitriptyline induces Gα(i/o) activation, which leads to GDNF expression in as...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kajitani, Naoto, Miyano, Kanako, Okada-Tsuchioka, Mami, Abe, Hiromi, Itagaki, Kei, Hisaoka-Nakashima, Kazue, Morioka, Norimitsu, Uezono, Yasuhito, Takebayashi, Minoru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207162/
https://ncbi.nlm.nih.gov/pubmed/27864362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753871
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