Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive Gα(i/o) Activation in Astroglial Cells

Further elaborating the mechanism of antidepressants, beyond modulation of monoaminergic neurotransmission, this study sought to elucidate the mechanism of amitriptyline-induced production of glial cell line-derived neurotrophic factor (GDNF) in astroglial cells. Previous studies demonstrated that a...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hisaoka-Nakashima, Kazue, Miyano, Kanako, Matsumoto, Chie, Kajitani, Naoto, Abe, Hiromi, Okada-Tsuchioka, Mami, Yokoyama, Akinobu, Uezono, Yasuhito, Morioka, Norimitsu, Nakata, Yoshihiro, Takebayashi, Minoru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447948/
https://ncbi.nlm.nih.gov/pubmed/25869129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.622415
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