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A Gastrointestinal Calpain Complex, G-calpain, Is a Heterodimer of CAPN8 and CAPN9 Calpain Isoforms, Which Play Catalytic and Regulatory Roles, Respectively

Calpains (CAPN) are a family of Ca(2+)-dependent cysteine proteases that regulate various cellular functions by cleaving diverse substrates. Of the 15 mammalian calpains, CAPN8 and CAPN9 are two that are expressed predominantly in the gastrointestinal tract, where they interact to form a protease co...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Hata, Shoji, Kitamura, Fujiko, Yamaguchi, Midori, Shitara, Hiroshi, Murakami, Makoto, Sorimachi, Hiroyuki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207157/
https://ncbi.nlm.nih.gov/pubmed/27881674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.763912
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