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G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway

G protein-coupled receptors (GPCRs) activate PI3K/v-AKT thymoma viral oncoprotein (AKT) to regulate many cellular functions that promote cell survival, proliferation, and growth. However, the mechanism by which GPCRs activate PI3K/AKT remains poorly understood. We used ovarian preantral granulosa ce...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Law, Nathan C., White, Morris F., Hunzicker-Dunn, Mary E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207145/
https://ncbi.nlm.nih.gov/pubmed/27856640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.763235
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