Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer

The antineoplastic agent benzyl isothiocyanate (BITC) acts by targeting multiple pro-oncogenic pathways/genes, including signal transducer and activator of transcription 3 (STAT3); however, the mechanism of action is not well known. As reported previously, BITC induced reactive oxygen species (ROS)...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Kasiappan, Ravi, Jutooru, Indira, Karki, Keshav, Hedrick, Erik, Safe, Stephen
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207142/
https://ncbi.nlm.nih.gov/pubmed/27875298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.746339
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