The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence

Many bacterial pathogens secrete virulence (effector) proteins that interfere with immune signaling in their host. SpvD is a Salmonella enterica effector protein that we previously demonstrated to negatively regulate the NF-κB signaling pathway and promote virulence of S. enterica serovar Typhimuriu...

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Vydáno v:J Biol Chem
Hlavní autoři: Grabe, Grzegorz J., Zhang, Yue, Przydacz, Michal, Rolhion, Nathalie, Yang, Yi, Pruneda, Jonathan N., Komander, David, Holden, David W., Hare, Stephen A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207060/
https://ncbi.nlm.nih.gov/pubmed/27789710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752782
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