Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space

Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysine residues in the telopeptides of fibrillar collagens, which leads to the formation of stable collagen cross-links. Recently we reported that LH2 enhances the metastatic propensity of lung cancer by increasing the amount of stable hydroxy...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Chen, Yulong, Guo, Houfu, Terajima, Masahiko, Banerjee, Priyam, Liu, Xin, Yu, Jiang, Momin, Amin A., Katayama, Hiroyuki, Hanash, Samir M., Burns, Alan R., Fields, Gregg B., Yamauchi, Mitsuo, Kurie, Jonathan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207055/
https://ncbi.nlm.nih.gov/pubmed/27803159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.759803
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