Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors

Elicitation of broadly neutralizing antibodies remains a long-standing goal of HIV vaccine research. Although such antibodies can arise during HIV-1 infection, gaps in our knowledge of their germline, pre-immune precursor forms, as well as on their interaction with viral Env, limit our ability to el...

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Dettagli Bibliografici
Pubblicato in:Cell Rep
Autori principali: Yacoob, Christina, Pancera, Marie, Vigdorovich, Vladimir, Oliver, Brian G., Glenn, Jolene A., Feng, Junli, Sather, D. Noah, McGuire, Andrew T., Stamatatos, Leonidas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207042/
https://ncbi.nlm.nih.gov/pubmed/27806295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.017
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