Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors

Elicitation of broadly neutralizing antibodies remains a long-standing goal of HIV vaccine research. Although such antibodies can arise during HIV-1 infection, gaps in our knowledge of their germline, pre-immune precursor forms, as well as on their interaction with viral Env, limit our ability to el...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cell Rep
Main Authors: Yacoob, Christina, Pancera, Marie, Vigdorovich, Vladimir, Oliver, Brian G., Glenn, Jolene A., Feng, Junli, Sather, D. Noah, McGuire, Andrew T., Stamatatos, Leonidas
פורמט: Artigo
שפה:Inglês
יצא לאור: 2016
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207042/
https://ncbi.nlm.nih.gov/pubmed/27806295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.017
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