Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning

Carbon monoxide (CO) is a leading cause of poisoning deaths worldwide, with no available antidotal therapy. We introduce a potential treatment paradigm for CO poisoning, based on near-irreversible binding of CO by an engineered human neuroglobin (Ngb). Ngb is a six-coordinate hemoprotein, with the h...

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Vydáno v:Sci Transl Med
Hlavní autoři: Azarov, Ivan, Wang, Ling, Rose, Jason J., Xu, Qinzi, Huang, Xueyin N., Belanger, Andrea, Wang, Ying, Guo, Lanping, Liu, Chen, Ucer, Kamil B., McTiernan, Charles F., O’Donnell, Christopher P., Shiva, Sruti, Tejero, Jesús, Kim-Shapiro, Daniel B., Gladwin, Mark T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206801/
https://ncbi.nlm.nih.gov/pubmed/27928027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aah6571
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