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Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons
Nuclear dysfunction in motor neurons has been hypothesized to be a principal cause of amyotrophic lateral sclerosis (ALS) pathogenesis. Here, we investigated the mechanism by which the nuclear pore complex (NPC) is disrupted in dying motor neurons in a mechanistic ALS mouse model (adenosine deaminas...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5206745/ https://ncbi.nlm.nih.gov/pubmed/28045133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39994 |
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