Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin

Cellular senescence is characterized by a permanent cell-cycle arrest and a pro-inflammatory secretory phenotype, and can be induced by a variety of stimuli, including ionizing radiation, oxidative stress, and inflammation. In endothelial cells, this phenomenon might contribute to vascular disease....

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Vydáno v:Sci Rep
Hlavní autoři: Khan, Shafaat Y., Awad, Ezzat M., Oszwald, Andre, Mayr, Manuel, Yin, Xiaoke, Waltenberger, Birgit, Stuppner, Hermann, Lipovac, Markus, Uhrin, Pavel, Breuss, Johannes M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206708/
https://ncbi.nlm.nih.gov/pubmed/28045034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39501
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