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Hierarchical CRMP2 posttranslational modifications control NaV1.7 function
Voltage-gated sodium channels are crucial determinants of neuronal excitability and signaling. Trafficking of the voltage-gated sodium channel NaV1.7 is dysregulated in neuropathic pain. We identify a trafficking program for NaV1.7 driven by hierarchical interactions with posttranslationally modifie...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5206544/ https://ncbi.nlm.nih.gov/pubmed/27940916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610531113 |
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