Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s

Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung. In Th2 cells, T cell receptor (TCR) signaling activates the transcription factors nuclear factor of activated T cell...

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Foilsithe in:J Exp Med
Main Authors: von Moltke, Jakob, O’Leary, Claire E., Barrett, Nora A., Kanaoka, Yoshihide, Austen, K. Frank, Locksley, Richard M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2017
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206504/
https://ncbi.nlm.nih.gov/pubmed/28011865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161274
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