Inherited CD70 deficiency in humans reveals a critical role for the CD70–CD27 pathway in immunity to Epstein-Barr virus infection

Epstein-Barr virus (EBV) infection in humans is a major trigger of malignant and nonmalignant B cell proliferations. CD27 is a co-stimulatory molecule of T cells, and inherited CD27 deficiency is characterized by high susceptibility to EBV infection, though the underlying pathological mechanisms hav...

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Publicado en:J Exp Med
Autores principales: Izawa, Kazushi, Martin, Emmanuel, Soudais, Claire, Bruneau, Julie, Boutboul, David, Rodriguez, Rémy, Lenoir, Christelle, Hislop, Andrew D., Besson, Caroline, Touzot, Fabien, Picard, Capucine, Callebaut, Isabelle, de Villartay, Jean-Pierre, Moshous, Despina, Fischer, Alain, Latour, Sylvain
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206497/
https://ncbi.nlm.nih.gov/pubmed/28011863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160784
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