Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility

Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection. RASGRP1 is a T‐lymphocyte‐specific nucleotide exchange factor known to activate the pathway of MAP kina...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Winter, Sarah, Martin, Emmanuel, Boutboul, David, Lenoir, Christelle, Boudjemaa, Sabah, Petit, Arnaud, Picard, Capucine, Fischer, Alain, Leverger, Guy, Latour, Sylvain
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801500/
https://ncbi.nlm.nih.gov/pubmed/29282224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708292
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