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Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile

DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of DNA replication in pathogenic microorganisms. Clost...

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Publicat a:Open Biol
Autors principals: van Eijk, Erika, Paschalis, Vasileios, Green, Matthew, Friggen, Annemieke H., Larson, Marilynn A., Spriggs, Keith, Briggs, Geoffrey S., Soultanas, Panos, Smits, Wiep Klaas
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204125/
https://ncbi.nlm.nih.gov/pubmed/28003473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160272
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