Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile

DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of DNA replication in pathogenic microorganisms. Clost...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: van Eijk, Erika, Paschalis, Vasileios, Green, Matthew, Friggen, Annemieke H., Larson, Marilynn A., Spriggs, Keith, Briggs, Geoffrey S., Soultanas, Panos, Smits, Wiep Klaas
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204125/
https://ncbi.nlm.nih.gov/pubmed/28003473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160272
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