Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile

DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of DNA replication in pathogenic microorganisms. Clost...

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Foilsithe in:Open Biol
Main Authors: van Eijk, Erika, Paschalis, Vasileios, Green, Matthew, Friggen, Annemieke H., Larson, Marilynn A., Spriggs, Keith, Briggs, Geoffrey S., Soultanas, Panos, Smits, Wiep Klaas
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Royal Society 2016
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204125/
https://ncbi.nlm.nih.gov/pubmed/28003473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160272
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